Ridha Samad

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Hello! My name is Ridha Samad and I am a current senior at Skyline High School, in Sammamish, WA. I am currently passionate about biomedical research, specifically focusing on tools for early detection of diseases such as cancer. I hope to use my skills and passion to make a positive impact on people's lives. Outside of school, I love to read books and spend time with friends and family! 

The DREAM-High Program has been such a unique and educational opportunity that I am grateful for. I have met and worked with so many wonderful teachers and students who have strengthened my computational and critical thinking skills. I have loved learning about the R programming language and hope to continue using it in a biological focus. Hearing from accomplished guest speakers has also been incredibly inspiring. .

Through hands-on programming, DREAM-High Scholars visualize and analyze genomics, clinical, and physical data from breast cancer cells. DREAM-High is a partnership between the Columbia Center for Cancer Systems Therapeutics, the Palazzo Strozzi Foundation USA, the Stanford Center for Cancer Systems Biology, and the Institute for Systems Biology. 

In the DREAM-High program, Scholars learn to program in R, a language for statistical computing and graphics. They manipulate and write code in a cloud-based RStudio environment to analyze a wide range of data on breast cancer patients and cancer cell lines. 

I created heat maps as colorized representations of data matrices. I reordered features and observations so that similar entities are close to each other in the graph.  Heat maps make it easy to visualize and understand complex data.

I loaded and examined a data frame of clinical information from 1,082 breast cancer patients from The Cancer Genome Atlas (TCGA). I summarized clinical measurements on both the patients, such as  gender and age, and the patients’ tumors, such as estrogen receptor status and histology.

I performed an integrative analysis of clinical measurements and gene expression data for 1,082 patients in the TCGA Breast Cancer cohort. By calculating heat maps and annotating them with clinical information, I detected patterns in the patients' expression profiles across 18,351 genes that correspond to luminal and triple negative breast cancers.

I discovered biological processes that distinguish cancer cell lines based on the aggressiveness of the cancers they model. For both breast cancer and colon cancer cell lines, I calculated, visualized, and functionally annotated differential gene expression profiles with data from the Physical Sciences in Oncology Cell Line Characterization Study.

I built linear regression models that are predictive of breast cancer survival from the METABRIC breast cancer dataset. I found that gene expression profiles of certain cancer genes are predictive of prognosis. Inclusion of additional features in my model increased its explanatory power.